Norfolk Study Explores the Effects of Lifestyle Interventions on Type 2 Diabetes

Norfolk Study Explores the Effects of Lifestyle Interventions on Type 2 Diabetes

JAMA Internal Medicine—a peer-reviewed medical journal by the American Medical Association—recently published the results of anindependent studythat was conducted over a 46-month period.

The Norfolk Diabetes Prevention Study (NDPS) investigated the effects of group-based lifestyle intervention (with or without the support (advice) of lay lifestyle volunteers with Type 2 diabetes) to prevent theprogression of Type 2 diabetes among a high-risk glycemic population.


Results of the Study

  • Lifestyle intervention (with or without support volunteers) significantly reduced the 2-year risk of type 2 diabetes by 40% - 47%.
  • For every 11 participants treated, 1 diabetes diagnosis was prevented.

Background of the Study

The NDPS consisted of 1,028 participants, all living with high-risk intermediate glycemic categories. Participants were then randomized into one of three arms: 

  1. A controlled arm that received ‘usual care’ (e.g. written information about diabetes and a single education session)
  2. An arm that received an intensive group-based diet and physical activity intervention (e.g. multiple interactive sessions) 
  3. An arm that received the same intervention as group 2, in addition to enhanced support from trained volunteers living with T2DM and diabetes prevention mentors (e.g. extra motivational and goal setting sessions) 

Beginning August 2011 through January 2019, the NDPS set out to examine whether preventative lifestyle changes can help reduce the risk of developing Type 2 diabetes. The first-of-its-kind clinical trial also aimed to investigate whether receiving advice from Type 2 diabetics and trained mentors would further reduce the progression of the disease.

At the completion of the study, the researchers reported that there were no significant differences between the intervention arms in the primary outcome, meaning enhancing the intervention with the support of diabetes prevention mentors did not further reduce the risk of participants developing Type 2 diabetes. However, they did conclude that each intervention arm had significantly lower odds of Type 2 diabetes.

To learn more about the study, visit theJAMA Internal Medicine website to read the full article.

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